Grief is a natural response to loss. It's the emotional suffering you feel when something or someone you love is taken away. Often the pain of loss can feel overwhelming. You may experience all kinds of difficult and unexpected emotions, from shock or anger to disbelief, guilt, and profound sadness. The pain of grief can also disrupt your physical health, making it difficult to sleep, eat, or even think straight. These are normal reactions to loss and the more significant the loss, the more intense your grief will be.